Prescription drug · Used for type 2 diabetes

Invokana side effects

canagliflozin

This side effect is printed on the FDA label for Invokana. It was a question in our daily quiz, where you pick the real side effect from four choices.

A higher risk of toe, foot or leg amputation

In two large trials, most amputations involved the toe and midfoot.

From the FDA label

“INVOKANA may increase your risk of lower limb amputations.”

Invokana label, updated Jun 11, 2026 · Read the full label on DailyMed

What to watch for

Check your feet every day. Tell your doctor about new pain, sores, ulcers or infections on your legs or feet.

3,296 reports to the FDA's adverse event system mention a toe, foot or leg amputation. A report is not proof the drug caused it. See the query

From quiz No. 14 · October 8, 2026 · Play that quiz →

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Not medical advice. Don't stop or start a medication because of a quiz. Talk to your doctor or pharmacist. Label text and report counts from openFDA. Not affiliated with any drug maker.