Your Side Effects May IncludePrednisone side effects
This side effect is printed on the FDA label for Prednisone. It was a question in our daily quiz, where you pick the real side effect from four choices.
Feeling unusually euphoric
Steroids can swing your mood both ways, from on top of the world to severe depression.
“Psychiatric derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations.”
Tell your doctor about big changes in mood or sleep. After long use, don't stop suddenly; the dose usually needs to come down gradually.
804 reports to the FDA's adverse event system mention euphoria or mood swings. A report is not proof the drug caused it. See the query
From quiz No. 7 · October 1, 2026 · Play that quiz →
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Not medical advice. Don't stop or start a medication because of a quiz. Talk to your doctor or pharmacist. Label text and report counts from openFDA. Not affiliated with any drug maker.