Your Side Effects May IncludeEntacapone (Comtan) side effects
This side effect is printed on the FDA label for Entacapone. It was a question in our daily quiz, where you pick the real side effect from four choices.
Brownish-orange urine
It looks alarming, but the label says it isn't harmful.
From the FDA label
“Tell patients that treatment with entacapone may cause a change in the color of their urine (a brownish orange discoloration) that is not clinically relevant.”
Entacapone label, updated May 13, 2026 ·
Read the full label on DailyMed
What to watch for
The color is harmless. Tell your doctor about new urges to gamble or spend, or falling asleep during daily activities.
19 reports to the FDA's adverse event system mention discolored urine. A report is not proof the drug caused it. See the query
From quiz No. 9 · October 3, 2026 · Play that quiz →
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Not medical advice. Don't stop or start a medication because of a quiz. Talk to your doctor or pharmacist. Label text and report counts from openFDA. Not affiliated with any drug maker.