Prescription drug · Used for osteoporosis

Prolia side effects

denosumab

This side effect is printed on the FDA label for Prolia. It was a question in our daily quiz, where you pick the real side effect from four choices.

Several broken spine bones after you stop it

The protection wears off when the shots stop. Fractures have come 7 to 43 months after the last injection.

From the FDA label

“Multiple vertebral fractures have been reported following Prolia discontinuation.”

Prolia label, updated Jun 26, 2026 · Read the full label on DailyMed

What to watch for

Don't stop Prolia without a plan from your doctor, and try not to miss doses.

3,365 reports to the FDA's adverse event system mention spine fractures. A report is not proof the drug caused it. See the query

From quiz No. 10 · October 4, 2026 · Play that quiz →

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Not medical advice. Don't stop or start a medication because of a quiz. Talk to your doctor or pharmacist. Label text and report counts from openFDA. Not affiliated with any drug maker.